Vasoactive intestinal peptide receptor

vasoactive intestinal peptide receptor 2
Identifiers
Symbol	VIPR2
Alt. symbols	VPAC2
NCBI gene	7434
HGNC	12695
OMIM	601970
RefSeq	NM_003382
UniProt	P41587
Other data
Locus	Chr. 7 q36.3
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

vasoactive intestinal peptide receptor 1
Identifiers
Symbol	VIPR1
Alt. symbols	RDC1, HVR1, VAPC1
NCBI gene	7433
HGNC	12694
OMIM	192321
RefSeq	NM_004624
UniProt	P32241
Other data
Locus	Chr. 3 p22
Search for
Structures	Swiss-model
Domains	InterPro

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Identifiers

Symbol

ADCYAP1R1

Alt. symbols

PACAPR

HGNC

OMIM

Other data

Chr. 7 p14

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Structures	Swiss-model
Domains	InterPro

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC₁ and VPAC₂.^[1]^[2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.

VPAC₁ is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.

VPAC₂ is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.^[3]

References

^ Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels. 8 (3–4): 137–53. doi:10.1080/10606820213680. PMID 12529932.
^ Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2–3): 165–73. doi:10.1016/S0167-0115(02)00099-X. PMID 12220741. S2CID 21588275.
^ "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).

External links

"VIP and PACAP Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Receptors,+Vasoactive+Intestinal+Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)

[pmid12529932-1] Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels. 8 (3–4): 137–53. doi:10.1080/10606820213680. PMID 12529932.

[pmid12220741-2] Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2–3): 165–73. doi:10.1016/S0167-0115(02)00099-X. PMID 12220741. S2CID 21588275.

[Guide_to_Pharmacology_VIP/PACAP_receptors-3] "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).

[1]

[2]

[3]