Urtoxazumab

Urtoxazumab
Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	E. coli Shiga-like toxin II B subunit
Clinical data
ATC code	none;
Identifiers
CAS Number	502496-16-4 ;
ChemSpider	none;
UNII	232D35B3NT;
Chemical and physical data
Formula	C6414H9934N1718O2010S40
Molar mass	144556.44 g·mol−1
	(verify)

Urtoxazumab is a humanized monoclonal antibody against diarrhoea caused by Escherichia coli, serotype O121. The drug is designed to bind to a toxin of this bacterium, so that it can be more easily broken down and eliminated from the body.^[1]^[2]

References

^ "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). World Health Organization.
^ López EL, Contrini MM, Glatstein E, González Ayala S, Santoro R, Allende D, et al. (January 2010). "Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli". Antimicrobial Agents and Chemotherapy. 54 (1): 239–43. doi:10.1128/AAC.00343-09. PMC 2798559. PMID 19822704.

[1] "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). World Health Organization.

[2] López EL, Contrini MM, Glatstein E, González Ayala S, Santoro R, Allende D, et al. (January 2010). "Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli". Antimicrobial Agents and Chemotherapy. 54 (1): 239–43. doi:10.1128/AAC.00343-09. PMC 2798559. PMID 19822704.

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