Suproclone

Suproclone
Clinical data
ATC code	none;
Identifiers
	IUPAC name [6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-propanoylpiperazine-1-carboxylate;
CAS Number	76535-71-2 ;
PubChem CID	53696;
ChemSpider	48481 ;
UNII	J4AM5D708G;
KEGG	D05975 ;
ECHA InfoCard	100.071.330
Chemical and physical data
Formula	C22H22ClN5O4S2
Molar mass	520.02 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N5CCN(C(=O)OC4C=1SCCSC=1C(=O)N4c2nc3nc(Cl)ccc3cc2)CC5)CC;
	InChI InChI=1S/C22H22ClN5O4S2/c1-2-16(29)26-7-9-27(10-8-26)22(31)32-21-18-17(33-11-12-34-18)20(30)28(21)15-6-4-13-3-5-14(23)24-19(13)25-15/h3-6,21H,2,7-12H2,1H3 ; Key:IBAUKGNDWVSETP-UHFFFAOYSA-N ;
	(verify)

Suproclone is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs, developed by the French pharmaceutical company Rhône-Poulenc.^[1] Other cyclopyrrolone drugs include zopiclone, pagoclone and suriclone.

Suproclone is very similar in structure to the related drug suriclone, but little information has been published about it specifically. However it can be expected that the mechanism of action by which suproclone produces its sedative and anxiolytic effects is by modulating benzodiazepine receptors (resulting in an increased response to endogenous GABA), in a similar manner to other drugs of this class.^[2]^[3]

References

^ Psychotropics.dk. "suproclone". Retrieved 24 August 2009.
^ Gardner CR (1988). "Pharmacological profiles in vivo of benzodiazepine receptor ligands". Drug Development Research. 12 (1): 1–28. doi:10.1002/ddr.430120102. S2CID 85573551.
^ Doble A, Martin I, Nutt D (23 October 2003). Calming the brain: benzodiazepines and related drugs from laboratory to clinic. Informa Healthcare. ISBN 1-84184-052-1.

[1] Psychotropics.dk. "suproclone". Retrieved 24 August 2009.

[2] Gardner CR (1988). "Pharmacological profiles in vivo of benzodiazepine receptor ligands". Drug Development Research. 12 (1): 1–28. doi:10.1002/ddr.430120102. S2CID 85573551.

[3] Doble A, Martin I, Nutt D (23 October 2003). Calming the brain: benzodiazepines and related drugs from laboratory to clinic. Informa Healthcare. ISBN 1-84184-052-1.

[1]

[2]

[3]

Clinical data

ATC code	none
Identifiers
IUPAC name [6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-propanoylpiperazine-1-carboxylate
CAS Number	76535-71-2
PubChem CID	53696
ChemSpider	48481
UNII	J4AM5D708G
KEGG	D05975
ECHA InfoCard	100.071.330
Chemical and physical data
Formula	C₂₂H₂₂ClN₅O₄S₂
Molar mass	520.02 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(N5CCN(C(=O)OC4C=1SCCSC=1C(=O)N4c2nc3nc(Cl)ccc3cc2)CC5)CC
InChI InChI=1S/C22H22ClN5O4S2/c1-2-16(29)26-7-9-27(10-8-26)22(31)32-21-18-17(33-11-12-34-18)20(30)28(21)15-6-4-13-3-5-14(23)24-19(13)25-15/h3-6,21H,2,7-12H2,1H3 Key:IBAUKGNDWVSETP-UHFFFAOYSA-N
(verify)