Phosphomevalonate kinase

PMVK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CH4
Identifiers
Aliases	PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDs	OMIM: 607622 MGI: 1915853 HomoloGene: 4779 GeneCards: PMVK
EC number	2.7.4.2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,936,719 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,469,013 bp
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • ATP binding; • kinase activity; • phosphomevalonate kinase activity;
Cellular component	• cytoplasm; • cytosol; • peroxisome; • extracellular exosome; • membrane;
Biological process	• cholesterol biosynthetic process; • steroid metabolic process; • isopentenyl diphosphate biosynthetic process, mevalonate pathway; • response to cholesterol; • cholesterol metabolic process; • sterol biosynthetic process; • isoprenoid biosynthetic process; • phosphorylation; • lipid metabolism; • steroid biosynthetic process; • regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10654
	68603
	ENSG00000163344
	ENSMUSG00000027952
	Q15126
	Q9D1G2
	NM_006556; NM_001323011; NM_001323012; NM_001348696
	NM_026784; NM_027348; NM_001310640
	NP_001309940; NP_001309941; NP_006547; NP_001335625
	NP_001297569; NP_081060; NP_081624
	Wikidata
View/Edit Human	View/Edit Mouse

Identifiers

Symbol

PMVK

HGNC

OMIM

Other data

EC number

Chr. 1 p13-q23

Search for
Structures	Swiss-model
Domains	InterPro

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway^[5]^[6]^[7] that in humans is encoded by the PMVK gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163344 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027952 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234: 2595–604. PMID 13801508.
^ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
^ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75: 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

Phosphomevalonate+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q15126 (Phosphomevalonate kinase) at the PDBe-KB.