Osiris is an Egyptian deity.
Osiris may also refer to:
Astronomy
- 1923 Osiris, an asteroid
- Osiris (lunar crater)
- Osiris (planet) or HD 209458 b, an extrasolar planet
- Osiris (Ganymede crater), a crater on Ganymede
- OSIRIS-REx, a NASA New Frontiers mission to return samples from an asteroid
- Odin-OSIRIS, an atmospheric measurement instrument
- OH-Suppressing Infrared Integral Field Spectrograph
- Optical System for Imaging and low Resolution Integrated Spectroscopy
- Optical, Spectroscopic, and Infrared Remote Imaging System
Entertainment
- Osiris: New Dawn, an action-adventure video game
- Osiris (DC Comics), any of three characters from DC Comics
- Osiris (Marvel Comics), a fictional character in the Marvel Comics universe
- Osiris (Stargate), a character in Stargate SG-1
- Osiris (funk band), 1970s funk band led by Tyrone Brunson
- Osiris (symphony), a symphony by Gamal El-Din Abdel Rehim
Other
- Osiris (genus), a genus of cleptoparasitic bees
- Osiris (journal), a scholarly journal on the history of science
- HMS Osiris, an Oberon-class submarine in the Royal Navy
- Osiris (Serverless Portal System)
- Osiris, Missouri, a community in the United States
- Osiris Shoes, a skateboarding footwear company
- Osiris, a South Devon Railway Comet class steam locomotive
- Daniel Iffla, French financier and philanthropist also known as Osiris