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A globoside is a type of glycosphingolipid with more than one sugar as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. A glycosphingolipid that has only one sugar as the side chain is called a cerebroside.
The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.[1]
References
- ^ Germain, D. P. (2002). "Fabry's disease (alpha-galactosidase-A deficiency): Physiopathology, clinical signs, and genetic aspects". Journal de la Société de Biologie. 196 (2): 161–73. doi:10.1051/jbio/2002196020161. PMID 12360745.
External links
Media related to Globósido at Wikimedia Commons- Globosides at the US National Library of Medicine Medical Subject Headings (MeSH)
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