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| Amlodipine | Calcium channel blocker |
| Valsartan | Angiotensin II receptor antagonist |
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| Trade names | Exforge |
| AHFS/Drugs.com | Professional Drug Facts |
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| Routes of administration | By mouth |
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Amlodipine/valsartan is a blood pressure lowering combination drug. It contains amlodipine, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin receptor blocker.[2] This combination is usually well tolerated and effective for the reduction of blood pressure.[3]
The combination was patented by Novartis Pharmaceuticals and sold under the brand name Exforge. The patent expired in September 2012.[4]
Amlodipine/valsartan is available in different dose preparations: 5 mg/160 mg, 10 mg/160 mg, 5 mg/320 mg and 10/320 mg of amlodipine and valsartan, respectively.[5]
The combination is also available with included hydrochlorothiazide, for patients who need a three-drug regimen to manage their blood pressure.[6]
References
- ^ a b "Amlodipine / valsartan (Exforge) Use During Pregnancy". Drugs.com. 11 July 2019. Retrieved 13 February 2020.
- ^ "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- ^ Eckert S, Freytag SB, Müller A, Klebs SH (September 2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors". Blood Pressure. 22 (sup1): 11–21. doi:10.3109/08037051.2013.793891. PMID 23713686. S2CID 25814898.
- ^ "Generic Exforge HCT". Blood-pressure.emedtv.com. Retrieved 2012-03-05.
- ^ "Exforge- amlodipine besylate and valsartan tablet, film coated". DailyMed. 12 June 2019. Retrieved 12 February 2020.
- ^ "Exforge HCT- amlodipine valsartan and hydrochlorothiazide tablet, film coated". DailyMed. Retrieved 12 February 2020.
External links
- "Amlodipine mixture with valsartan". Drug Information Portal. U.S. National Library of Medicine.
- "Amlodipine besylate mixture with hydrochlorothiazide and valsartan". Drug Information Portal. U.S. National Library of Medicine.