| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | alpha-v beta-3 integrin |
| Clinical data | |
| Trade names | Abegrin |
| ATC code |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6392H9908N1732O1996S42 |
| Molar mass | 144302.22 g·mol−1 |
| (verify) | |
Etaracizumab, also known as etaratuzumab, MEDI-522, trade name Abegrin, is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer,[1] ovarian cancer[2] and various other types of cancer.[3] It is manufactured by MedImmune.[1]
It is an enhanced iteration of Vitaxin, also known as MEDI-523. Both are derived from the mouse antibody LM609.[4]
References
- ^ a b "Etaracizumab" (PDF). Statement On A Nonproprietary Name Adopted By The Usan Council.
- ^ Landen CN, Kim TJ, Lin YG, Merritt WM, Kamat AA, Han LY, et al. (November 2008). "Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer". Neoplasia. 10 (11): 1259–67. doi:10.1593/neo.08740. PMC 2570602. PMID 18953435.
- ^ Delbaldo C, Raymond E, Vera K, Hammershaimb L, Kaucic K, Lozahic S, et al. (February 2008). "Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors". Investigational New Drugs. 26 (1): 35–43. doi:10.1007/s10637-007-9077-0. PMID 17876527. S2CID 37221398.
- ^ McNeel DG, Eickhoff J, Lee FT, King DM, Alberti D, Thomas JP, et al. (November 2005). "Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion". Clinical Cancer Research. 11 (21): 7851–60. doi:10.1158/1078-0432.CCR-05-0262. PMID 16278408.