DNQX

DNQX
Names
	IUPAC name 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
Identifiers
CAS Number	2379-57-9 ;
3D model (JSmol)	Interactive image;
ChemSpider	3123097 ;
DrugBank	DB03759 ;
PubChem CID	3899541;
UNII	62T278S1MX;
CompTox Dashboard (EPA)	DTXSID50274395 ;
	InChI InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N ; InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N;
	SMILES O=c2[nH]c1cc(N(=O)=O)c(N(=O)=O)cc1[nH]c2=O;
Properties
Chemical formula	C8H4N4O6
Molar mass	252.142 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

DNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies.^[1] It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.

References

^ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R (September 2010). "Glutamate receptor ion channels: structure, regulation, and function". Pharmacological Reviews. 62 (3): 405–96. doi:10.1124/pr.109.002451. PMC 2964903. PMID 20716669.

External links

DNQX MSDS

[1] Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R (September 2010). "Glutamate receptor ion channels: structure, regulation, and function". Pharmacological Reviews. 62 (3): 405–96. doi:10.1124/pr.109.002451. PMC 2964903. PMID 20716669.

[1]

Names


IUPAC name 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
Identifiers
CAS Number	2379-57-9
3D model (JSmol)	Interactive image
ChemSpider	3123097
DrugBank	DB03759
PubChem CID	3899541
UNII	62T278S1MX
CompTox Dashboard (EPA)	DTXSID50274395
InChI InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N
SMILES O=c2[nH]c1cc(N(=O)=O)c(N(=O)=O)cc1[nH]c2=O
Properties
Chemical formula	C₈H₄N₄O₆
Molar mass	252.142 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

DNQX

See also

References

External links