Coptisine

Coptisine
Names
	IUPAC name 6,7-Dihydro-bis(1,3)benzodioxolo (5,6-a:4',5'-g)quinolizinium
Identifiers
CAS Number	3486-66-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL362071 ;
ChemSpider	65268 ;
PubChem CID	72322;
UNII	0GCL71VN14 ;
CompTox Dashboard (EPA)	DTXSID10188404 ;
	InChI InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1 Key: XYHOBCMEDLZUMP-UHFFFAOYSA-N ; InChI=1/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1 Key: XYHOBCMEDLZUMP-UHFFFAOYAS;
	SMILES O1c3c(OC1)c2c[n+]6c(cc2cc3)c5cc4OCOc4cc5CC6;
Properties
Chemical formula	C19H14NO4+
Molar mass	320.319
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis),^[1] greater celandine, and opium.^[2] Famous for the bitter taste that it produces, it is used in Chinese herbal medicine along with the related compound berberine for digestive disorders caused by bacterial infections.^[3]

References

^ Chen J, Wang F, Liu J, Lee FS, Wang X, Yang H (April 2008). "Analysis of alkaloids in Coptis chinensis Franch by accelerated solvent extraction combined with ultra performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections". Analytica Chimica Acta. 613 (2): 184–95. doi:10.1016/j.aca.2008.02.060. PMID 18395058.
^ Hakim, Sohrab A. E.; Mijović, Valerie; Walker, James (1961). "Distribution of Certain Poppy-Fumaria Alkaloids and a Possible Link with the Incidence of Glaucoma". Nature. 189 (4760): 198–201. doi:10.1038/189198a0. PMID 13710637.
^ Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y (October 2009). "Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations". Journal of Ethnopharmacology. 126 (1): 5–17. doi:10.1016/j.jep.2009.08.009. hdl:10722/127599. PMID 19686830.

[pmid18395058-1] Chen J, Wang F, Liu J, Lee FS, Wang X, Yang H (April 2008). "Analysis of alkaloids in Coptis chinensis Franch by accelerated solvent extraction combined with ultra performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections". Analytica Chimica Acta. 613 (2): 184–95. doi:10.1016/j.aca.2008.02.060. PMID 18395058.

[2] Hakim, Sohrab A. E.; Mijović, Valerie; Walker, James (1961). "Distribution of Certain Poppy-Fumaria Alkaloids and a Possible Link with the Incidence of Glaucoma". Nature. 189 (4760): 198–201. doi:10.1038/189198a0. PMID 13710637.

[pmid19686830-3] Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y (October 2009). "Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations". Journal of Ethnopharmacology. 126 (1): 5–17. doi:10.1016/j.jep.2009.08.009. hdl:10722/127599. PMID 19686830.

[1]

[2]

[3]

Names

IUPAC name 6,7-Dihydro-bis(1,3)benzodioxolo (5,6-a:4',5'-g)quinolizinium
Identifiers
CAS Number	3486-66-6
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL362071
ChemSpider	65268
PubChem CID	72322
UNII	0GCL71VN14
CompTox Dashboard (EPA)	DTXSID10188404
InChI InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1 Key: XYHOBCMEDLZUMP-UHFFFAOYSA-N InChI=1/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1 Key: XYHOBCMEDLZUMP-UHFFFAOYAS
SMILES O1c3c(OC1)c2c[n+]6c(cc2cc3)c5cc4OCOc4cc5CC6
Properties
Chemical formula	C₁₉H₁₄NO₄+
Molar mass	320.319
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).