Cardiotoxin III

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Structures	Swiss-model
Domains	InterPro

Cytotoxin 3
Identifiers
Organism	Naja atra
Symbol	?
PDB	1H0J
UniProt	P60301
Search for
Structures	Swiss-model
Domains	InterPro

Cardiotoxin III (CTX III, also known as cytotoxin 3) is a sixty amino-acid polypeptide toxin from the Taiwan Cobra Naja atra. It is an example of a group of snake cardio/cytotoxins (InterPro: IPR003572), which are made up of shorter snake venom three-finger toxins.^[1]

Recent evidence has shown that CTX III may induce apoptosis in K562 cells via the release of cytochrome c.^[2]

References

^ "Superfamily » 2.2.39. Snake toxin-like (2 families) - Orientations of Proteins in Membranes (OPM) database". Retrieved 2008-12-13.
^ Yang SH, Chien CM, Lu MC, Lu YJ, Wu ZZ, Lin SR (July 2005). "Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway". Clin. Exp. Pharmacol. Physiol. 32 (7): 515–20. doi:10.1111/j.1440-1681.2005.04223.x. PMID 16026508.

[urlSuperfamily_»_2.2.39._Snake_toxin-like_(2_families)_-_Orientations_of_Proteins_in_Membranes_(OPM)_database-1] "Superfamily » 2.2.39. Snake toxin-like (2 families) - Orientations of Proteins in Membranes (OPM) database". Retrieved 2008-12-13.

[pmid16026508-2] Yang SH, Chien CM, Lu MC, Lu YJ, Wu ZZ, Lin SR (July 2005). "Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway". Clin. Exp. Pharmacol. Physiol. 32 (7): 515–20. doi:10.1111/j.1440-1681.2005.04223.x. PMID 16026508.

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