CSF2RB

CSF2RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C8P, 1EGJ, 1GH7, 2GYS, 4NKQ, 5DWU, 2NA9, 2NA8
Identifiers
Aliases	CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDs	OMIM: 138981 MGI: 1339760 HomoloGene: 339 GeneCards: CSF2RB
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,940,439 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,305,721 bp
Gene ontology
Molecular function	• interleukin-3 receptor activity; • interleukin-5 receptor activity; • GO:0001948 protein binding; • cytokine receptor activity; • protein tyrosine kinase activity; • Ras guanyl-nucleotide exchange factor activity; • signaling receptor activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • integral component of plasma membrane; • granulocyte macrophage colony-stimulating factor receptor complex; • intracellular;
Biological process	• cellular protein metabolic process; • respiratory gaseous exchange; • MAPK cascade; • signal transduction; • response to lipopolysaccharide; • peptidyl-tyrosine phosphorylation; • interleukin-5-mediated signaling pathway; • cellular response to interleukin-3; • interleukin-3-mediated signaling pathway; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1439
	12984
	ENSG00000100368
	ENSMUSG00000071714
	P32927
	P26954
	NM_000395
	NM_001287389; NM_007781
	NP_000386
	NP_001274318; NP_031807
	Wikidata
View/Edit Human	View/Edit Mouse

CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

GM-CSF receptor
IL-3 receptor
IL-5 receptor.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100368 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071714 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

External links

Cytokine+Receptor+Common+beta+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P32927 (Human Cytokine receptor common subunit beta (CSF2RB)) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100368 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071714 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Woodcock_1994-5] Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

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