Bolaamphiphiles (also known as bolaform surfactants, bolaphiles, or alpha-omega-type surfactants) are amphiphilic molecules that have hydrophilic groups at both ends of a sufficiently long hydrophobic hydrocarbon chain. Compared to single-headed amphiphiles, the introduction of a second head-group generally induces a higher solubility in water, an increase in the critical micelle concentration (cmc), and a decrease in aggregation number. The aggregate morphologies of bolaamphiphiles include spheres, cylinders, disks, and vesicles. Bolaamphiphiles are also known to form helical structures that can form monolayer microtubular self-assemblies.[1]
References
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Feng Qiu, Chengkang Tang, Yongzhu Chen Amyloid-like aggregation of designer bolaamphiphilic peptides: Effect of hydrophobic section and hydrophilic heads. Journal of peptide science. (2017) DOI: 10.1002/psc.3062
- ^ P/ Mosae Selvakumar et al, J. Mol. Struct. 919 (2009) 72-78