Aprobarbital

Aprobarbital
Clinical data
Other names	aprobarbital, Oramon, allylpropymal, Alurate, 5-isopropyl- 5-allylbarbituric acid
AHFS/Drugs.com	International Drug Names
ATC code	N05CA05 (WHO) ;
Legal status
Legal status	CA: Schedule IV ;
Identifiers
	IUPAC name 5-propan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione;
CAS Number	77-02-1 ;
PubChem CID	6464;
DrugBank	DB01352 ;
ChemSpider	6221 ;
UNII	Q0YKG9L6RF;
KEGG	D00698 ;
ChEBI	CHEBI:2791 ;
ChEMBL	ChEMBL7863 ;
CompTox Dashboard (EPA)	DTXSID8022616 ;
ECHA InfoCard	100.000.908
Chemical and physical data
Formula	C10H14N2O3
Molar mass	210.233 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(C(C)C)C\C=C;
	InChI InChI=1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15) ; Key:UORJNBVJVRLXMQ-UHFFFAOYSA-N ;
	(verify)

Aprobarbital (or aprobarbitone), sold as Oramon, Somnifaine, and Allonal, is a barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia.^[1] Aprobarbital was never as widely used as more common barbiturate derivatives such as phenobarbital and is now rarely prescribed as it has been replaced by newer drugs with a better safety margin.

References

^ Reddemann H, Türk E (May 1966). "[Oramon poisoning in infancy and childhood. Observations on 12 aprobarbital poisonings]". Das Deutsche Gesundheitswesen (in German). 21 (19): 878–81. PMID 5973760.

[pmid5973760-1] Reddemann H, Türk E (May 1966). "[Oramon poisoning in infancy and childhood. Observations on 12 aprobarbital poisonings]". Das Deutsche Gesundheitswesen (in German). 21 (19): 878–81. PMID 5973760.

[1]

Aprobarbital

See also

References