| Autoantibody | |
|---|---|
| Anti-p62 | |
| Autoantigen Isoform | Nucleoporin 62kDA |
| Autoantigen gene | NUP62 |
| Affected organ(s) | Bile duct |
| Associated Disease(s) | Primary biliary cirrhosis |
| HLA associations | DR2 (weak) |
Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.[1] The p62 protein is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.[2][3] The autoantigen is the nucleoporin 62kDA protein.
References
- ^ Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology. 110 (3): 840–7. doi:10.1053/gast.1996.v110.pm8608894. PMID 8608894.
- ^ Miyachi K, Hankins RW, Matsushima H, et al. (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247–54. doi:10.1016/S0896-8411(03)00033-7. PMID 12753810.
- ^ Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298–310. doi:10.1055/s-2005-916321. PMID 16143945.