Tooth and Nail may refer to:
- Tooth and Nail (various artists album), a 1979 compilation album featuring Californian punk rock bands
- Tooth and Nail (Dokken album), a 1984 album by heavy metal band Dokken, and a song from that album
- "Tooth and Nail", a 1984 song by Foreigner from the album Agent Provocateur
- Tooth and Nail (novel), a 1992 novel by Ian Rankin
- Tooth & Nail Records, a record label founded in 1993
- Tooth and Nail (film), a 2007 horror film
- Tooth & Nail (Billy Bragg album), a 2013 album by Billy Bragg
- Tooth and nail syndrome, a rare disorder characterized by nails that are thin, small, and friable
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