Substance may refer to:
- Substance (Jainism), a term in Jain Ontology to denote the base or owner of attributes
- Chemical substance, a material with a definite chemical composition
- Matter, anything that has mass and takes up space
- Substance theory, an ontological theory positing that a substance is distinct from its properties
- Ousia, term for substance in ancient Greek philosophy
Relating to drugs
- Drug substance
- Substance abuse, drug-related healthcare and social policy diagnosis or label
- Substance dependence, drug-related healthcare and social policy diagnosis or label
Arts, entertainment, and media
Music
- Substance (Blank & Jones album), 2002
- Substance (Joy Division album), 1988
- Substance 1987, a New Order album
- "Substance", a song by Haste the Day on the album That They May Know You
Other media
- SubStance, an interdisciplinary journal on literature published by the University of Wisconsin Press
- Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty
Religion
- Dravya, a term used in Jain texts to refer a substance
- Homoousion, a Christian term meaning "same substance"
- Homoiousian, a Christian term meaning "similar substance"
See also
- Substance control (disambiguation)
- Substantial (rapper)