His or HIS may refer to:
Computing
- Hightech Information System, a Hong Kong graphics card company
- Honeywell Information Systems
- Hybrid intelligent system
- Microsoft Host Integration Server
Education
- Hangzhou International School, in China
- Harare International School in Zimbabwe
- Hokkaido International School, in Japan
- Hsinchu International School, in Taiwan
Health and medicine
- Bundle of His, a collection of specialized heart cells
- Health information system
- Hospital information system
- His-tag, a polyhistidine motif in proteins
- Histidine, an amino acid
People
- Wilhelm His, Sr. (1831–1904), Swiss anatomist
- Wilhelm His, Jr. (1863–1934), Swiss anatomist
Places
- His, Agder, a village in Arendal municipality in Agder county, Norway
Other uses
- His, the possessive form of the English-language pronoun he
- H.I.S. (travel agency), a Japanese travel agency
- His, Haute-Garonne, a commune in the Haute-Garonne departement, France
- B sharp, known as His in some European countries
See also
- Hiss (disambiguation)