TSR may refer to:
Science and technology
- Terminate and stay resident program, a type of MS-DOS computer program
- Thermochemical sulfate reduction, a step in the sulfur cycle that reduces sulfate to sulfide
- Tip-speed ratio, a measurement used for wind turbines
- Temporary speed restriction, UK railway term
- Traffic-sign recognition, by equipment in vehicles
Military
- BAC TSR-2, a prototype British bomber (TSR = Tactical Strike/Reconnaissance)
- TSR I and II, prototypes of the Fairey Swordfish torpedo bomber
- FN Tactical Sport Rifle, manufactured by FN Herstal
Arts, media and culture
- TSR (company) (originally Tactical Studies Rules), game publisher
- Télévision Suisse Romande, a French language Swiss TV channel
- Full Metal Panic! The Second Raid, an anime
- The Shadow Rising, novel by Robert Jordan
- The Sims Resource, a fan site for The Sims
- True Symphonic Rockestra, an opera-oriented project
- The Student Room, UK internet forum
- Team Sonic Racing, a 2019 kart racing video game
- The Slow Rush, an album by Tame Impala released in 2020
Organizations
- Telford Steam Railway, a heritage line in the UK
- Toronto Street Railway, a horsecar system operating in Toronto from 1861 to 1891
- Toronto Suburban Railway, a former streetcar system in west Toronto and a former radial (interurban) line to Guelph
- Timișoara Traian Vuia International Airport, near Timişoara, Romania, IATA code
- Trans-Siberian Railway, a network of railways connecting Moscow with the Russian Far East
- TSR Records, a record label
Other uses
- TSR, abbreviation for travelling stock route, referring to stock routes in Australia
- Treno Servizio Regionale, a series of Italian electrical multiple unit trains
- Total shareholder return, a measure of the performance of different companies' stocks and shares over time
- Team Sonic Racing, a kart racing video game by Sega and a spinoff to the Sonic the Hedgehog series