Somatostatin receptor

somatostatin receptor 2
Identifiers
Symbol	SSTR2
NCBI gene	6752
HGNC	11331
OMIM	182452
RefSeq	NM_001050
UniProt	P30874
Other data
Locus	Chr. 17 q24
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

somatostatin receptor 1
Identifiers
Symbol	SSTR1
NCBI gene	6751
HGNC	11330
OMIM	182451
RefSeq	NM_001049
UniProt	P30872
Other data
Locus	Chr. 14 q13
Search for
Structures	Swiss-model
Domains	InterPro

Image showing somatostatin biochemical pathway complete with target cell somatostatin receptor

somatostatin receptor 3

Identifiers

Symbol

SSTR3

HGNC

OMIM

Other data

Chr. 22 q13.1

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Structures	Swiss-model
Domains	InterPro

somatostatin receptor 4

Identifiers

Symbol

SSTR4

HGNC

OMIM

Other data

Chr. 20 p11.2

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Structures	Swiss-model
Domains	InterPro

somatostatin receptor 5

Identifiers

Symbol

SSTR5

HGNC

OMIM

Other data

Chr. 16 p13.3

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Structures	Swiss-model
Domains	InterPro

Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.^[1]

There are five known somatostatin receptors:^[2]

SST₁ (SSTR1)
SST₂ (SSTR2)
SST₃ (SSTR3)
SST₄ (SSTR4)
SST₅ (SSTR5)

All are G protein-coupled seven transmembrane receptors.

References

^ Lou L (2016). Principles of Neurobiology. New York, NY: Garland Science, Taylor and Francis Group. pp. 109–110. ISBN 978-0-8153-4494-0.
^ Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86–8. doi:10.1016/S0165-6147(00)88988-9. PMID 7792934.

External links

Somatostatin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

[1] Lou L (2016). Principles of Neurobiology. New York, NY: Garland Science, Taylor and Francis Group. pp. 109–110. ISBN 978-0-8153-4494-0.

[pmid7792934-2] Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86–8. doi:10.1016/S0165-6147(00)88988-9. PMID 7792934.

[1]

[2]