Santa Isabel may refer to:
People
- Elizabeth of Portugal
- Isabelle of France (saint)
Places
Argentina
- Santa Isabel, Buenos Aires, a settlement in General Alvear Partido
- Santa Isabel, Córdoba, a neighbourhood in the city of Córdoba
- Santa Isabel, La Pampa, in the province of La Pampa
Brazil
- Santa Isabel, Espírito Santo, a town in the state of Espírito Santo
- Santa Isabel, Goiás, a town in the state of Goiás
- Santa Isabel, São Paulo, a town in the state of São Paulo
- Santa Isabel do Rio Negro, in the state of Amazonas
- Vila Santa Isabel, a neighborhood in Carrão (district of São Paulo)
Cape Verde
- Santa Isabel (Boa Vista), a parish on the island of Boa Vista
Colombia
- Santa Isabel (Bogotá), a barrio (neighborhood) in Bogotá
- Santa Isabel, Tolima, a town in Tolima department
- Santa Isabel (TransMilenio), a station on Bogotá's TransMilenio mass-transit system
- Santa Isabel (volcano), a volcano
Cuba
- Santa Isabel de las Lajas, historical and cultural name of the city of Lajas, Cuba
Equatorial Guinea
- Former name of Malabo, the country's capital
- Former name of Pico Basilé, highest mountain in Equatorial Guinea
Mexico
- Santa Isabel, Baja California, a city in the state of Baja California
- Santa Isabel, Chihuahua, a city in the state of Chihuahua
- Santa Isabel Municipality, also in Chihuahua
- Santa Isabel Cholula, in the state of Puebla
Panama
- Santa Isabel, Colón, a corregimiento (district subdivision) in Santa Isabel District
Philippines
- Santa Isabel, San Pablo, a barangay (administrative district) of San Pablo, Laguna Province
Portugal
- Santa Isabel (Lisbon), a former parish, extant from 1741–2012
Solomon Islands
- Santa Isabel Island, an island in the South Pacific
United States
- Santa Isabel de Utinahica, a former Spanish mission in the state of Georgia
Puerto Rico
- Santa Isabel, Puerto Rico, a municipality located on the southern coast
Venezuela
- Santa Isabel, Trujillo, the shire town of municipality Andrés Bello in Trujillo (state)
Other
- Santa Isabel languages, spoken in the Solomon Islands
- Santa Isabel Theater, in Recife, Brazil
- Santa Isabel (supermarkets) of Chile
- Santa Isabel (church) in Lisbon, Portugal
- SS Santa Isabel, a number of ships with this name