Potomac may refer to:
Places in the United States
Washington, D.C. area:
- The Potomac River, which flows through West Virginia, Maryland, Virginia, and Washington, D.C.
- The Potomac Highlands of West Virginia, a region of the Potomac River's watershed in West Virginia
- Potomac, Maryland, an unincorporated area in Montgomery County
- Potomac Airfield, a general aviation airport in Fort Washington, Maryland
- Potomac Park, Maryland, in Allegany County
- Potomac, Virginia, an extinct town formerly located in Arlington County
Other places in the U.S.:
- Potomac, Illinois, a village in Vermilion County
- Potomac, Montana, an unincorporated community in Missoula County
- Potomac, West Virginia, an unincorporated community
Vessels
- USS Potomac, one of six ships
- Potomac (tug), a Patapsco Class tug built for Vane Brothers Company
Other uses
- Patawomeck (or Potomac), a Native American tribe for whom the Potomac River was named
- Army of the Potomac, a major Union army during the American Civil War
- 1345 Potomac, an asteroid
- Potomac Computer Systems, a former name of Epic Games
- Potomac Horse Fever, a disease in horses
- Potomac Lake, an artificial lake in Gunnersbury Park, London commissioned by Lionel Nathan Rothschild.
- University of the Potomac, a degree-granting college based in Washington, D.C.
- Several former Amtrak passenger trains:
- Potomac (Amtrak train)
- Potomac Special
- Potomac Turbo