OPC may refer to:
Architecture and engineering
- Optical proximity correction
- Ordinary Portland cement
- Organic Photo Conductor, an element used for, among other applications, photocopier and laser printer drums.
Computing
- Open Packaging Conventions, a container-file technology created by Microsoft to store a combination of XML and non-XML files
- Open Platform Communications (OPC, which formerly stood for "OLE for Process Control"), in MPDV
- OPC Foundation, a related consortium
- Operations Planning and Control, renamed to IBM Tivoli Workload Scheduler (TWS)
- Optimized Power Control, a method to adjust laser power when writing optical media.
- Other Peoples' Computers - reference to privacy issues of cloud data being on somebody else's computer rather than your own and potential security issues.
Medicine and natural sciences
- Ocean Prediction Center
- Oligodendrocyte precursor cell
- Oligomeric proanthocyanidin
- Oropharyngeal cancer
Social matters, politics and government
- Obama Presidential Center
- (Federal) Office for the Protection of the Constitution, a translation of the German name Bundesamt für Verfassungsschutz
- Office of Policy Coordination, a secret U.S. government unit, 1948–1952
- Office of the Parliamentary Counsel (United Kingdom)
- Office of the Privacy Commissioner of Canada
- Online Party of Canada
- Oodua Peoples Congress, militant Yoruba nationalist organization situated in Nigeria
- Orthodox Presbyterian Church
- Orthodox Presbyterian Church of Korea
- Overseas Press Club
Other
- O-Pee-Chee, a Canadian sports card company
- Onnuri Presbyterian Church, a South Korean megachurch
- Ontario Pioneer Camp, in Huntsville, Ontario, Canada
- Ontario Police College
- OPC, Opel Performance Center a division of car manufacturer Opel
- Optional Payment Charge, a surcharge applied when paying by credit card for airline flights
- Organisation pour la prévention de la cécité (Organisation for the Prevention of Blindness), a French blindness charity working in Africa
- Orthotic Prosthetic Center