OIC or Organisation of Islamic Cooperation is an international organization formerly known as the Organisation of the Islamic Conference.
OIC may also refer to:
- Offer in compromise to reduce debt to the Internal Revenue Service
- Officer in Charge (Philippines), a specific status of a temporary head of a local government or agency in the Philippines
- Officer in charge (police), a gazetted officer in command of a police station in Sri Lanka
- Officer in Command (U.S. uniformed services)
- Two incarnations of the Oklahoma Intercollegiate Conference: Oklahoma Intercollegiate Conference (1914–1928), Oklahoma Intercollegiate Conference (1974–1997)
- Open Interconnect Consortium
- Opioid-induced constipation
- Order of the Imitation of Christ, a monastic order in the Syro-Malankara Catholic Church
- Orkney Islands Council, the local government authority for the Orkney Islands of Scotland, United Kingdom
- OIC, IATA code for Lt. Warren Eaton Airport, Norwich, New York
- Octahydroindole-2-carboxylic Acid (Oic)
- Office of the Independent Counsel
- Outline in Color, an American rock band from Tulsa, Oklahoma