MacManus is a family name that may refer to:
- Annie MacManus (a.k.a. Annie Mac) (b. 1978) - Irish DJ and television presenter
- Arthur MacManus (1889–1927) - Scottish trade unionist, political activist
- Diana MacManus (born 1986) - US athlete in swimming
- Dony MacManus (fl. 1990–present) - Irish sculptor, educator
- Emily MacManus (1886–1978) - Irish nurse, OBE recipient
- Declan MacManus (a.k.a. Elvis Costello) (b. 1954) - English musician, singer and songwriter (son of Ross MacManus)
- Francis MacManus (1909–1965) - Irish novelist
- Henry MacManus (c. 1810–1878) - Irish painter
- Joseph MacManus (1970–1992) - member in the Sligo Brigade of the Provisional Irish Republican Army
- Rosina MacManus (d. 2008) - Irish supporter of Camogie Association
- Ross MacManus (1927-2011) - British musician (father of Elvis Costello)
- Seán MacManus (politician) (b. 1950) - Irish political figure, father of Joseph MacManus
- Seumas MacManus (1869–1960) - Irish author, dramatist, poet
- Steve MacManus (b. 1953) - British comic writer, author, editor
- Terence MacManus (c. 1811–1861) - Irish rebel
- Theodore F. MacManus (1872–1940) - US advertisingman
- Tristan MacManus (b. 1982) - Irish dancer
See also
- McManus (disambiguation)