MSH may refer to:
- Maharashtra State Highway, see List of state highways in Maharashtra
- Management Sciences for Health, an NGO that maintains the International Medical Products Price Guide
- Markham Stouffville Hospital, a hospital in Markham, Ontario
- Marvel Super Heroes (disambiguation), an acronym commonly used by comic, arcade game and role-playing fans
- Melanocyte-stimulating hormone, a hormone produced in the pituitary gland, and related to skin pigmentation
- Microsoft Surface Hub
- Mississippi State Hospital, a mental hospital in Rankin County, Mississippi
- Monad Shell, a former name for the Microsoft Windows PowerShell
- Mossley Hill railway station, England; National Rail station code MSH
- Mount St. Helens, United States, often abbreviated as MSH
- Mount Sinai Hospital, Toronto
- Mycothiol, an unusual thiol that is found in Actinobacteria