The following highways are numbered 181:
Canada
- Prince Edward Island Route 181
Chile
- Route 181-CH in Araucanía Region
India
National Highway 181 (India)
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Ireland
R181 road (Ireland)
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Japan
Japan National Route 181
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United Kingdom
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United States
Interstate 181 (former)
U.S. Route 181
Alabama State Route 181
Arizona State Route 181
Arkansas Highway 181
California State Route 181
Connecticut Route 181
Florida State Road 181 (former)
Georgia State Route 181 (former)- Georgia State Route 181
Illinois Route 181 (former)
Iowa Highway 181 (former)
K-181 (Kansas highway)
Kentucky Route 181
Louisiana Highway 181
Maine State Route 181
Maryland Route 181- Massachusetts Route 181
M-181 (Michigan highway) (former)
Missouri Route 181
New Jersey Route 181
New Mexico State Road 181
New York State Route 181 (former)
North Carolina Highway 181
Ohio State Route 181
Pennsylvania Route 181
South Carolina Highway 181
Tennessee State Route 181
Utah State Route 181 (former)
Texas State Highway 181 (former) 
Texas State Highway Loop 181
Farm to Market Road 181 (Texas)
Virginia State Route 181
Washington State Route 181
Wisconsin Highway 181
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Territories:
Puerto Rico Highway 181
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| Previous | Lists of highways | Next |
|---|---|---|
| 180 | 181 | 182 |