| Type II cytokine receptor | |
|---|---|
| Identifiers | |
| Symbol | Type II cytokine receptor |
| Pfam clan | CL0159 |
| Membranome | 2 |
| Interferon gamma receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | IFNGR1 | ||||||||
| Pfam | PF07140 | ||||||||
| InterPro | IPR021126 | ||||||||
| SCOP2 | 1fg9 / SCOPe / SUPFAM | ||||||||
| |||||||||
| Interferon-alpha/beta receptor, fibronectin type III | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Interfer-bind | ||||||||
| Pfam | Interfer-bind | ||||||||
| InterPro | IPR015373 | ||||||||
| SCOP2 | 1n6u / SCOPe / SUPFAM | ||||||||
| |||||||||
Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors.
Structure
Typically type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The structure of extracellular domain of one such receptor, the Interferon-gamma receptor in complex with IFNγ, has been determined by x-ray crystallography.[1] This complex has a 2:2:2 stoichiometry, with two copies each of the IFNγR1 and IFNγR2 monomers contacting the IFNγ dimer. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.
Types
Type II cytokine receptors include those that bind type I and type II interferons, and those that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22).[2][3]
Interferon receptors
The interferon receptor is a molecule displayed on the surface of cells which allows them to interact with the anti-viral substance interferon. The receptor is genetically coded for by number of different genes, as there are a few distinct types of interferon. Interferon receptor deficiency is a condition showing some amenability to genetic therapy.[4]
- interferon-alpha/beta receptor
- interferon-gamma receptor
- Interferon type III receptor
Interleukin receptors
- Interleukin-10 receptor
- Interleukin-20 receptor
- Interleukin-22 receptor
- Interleukin-28 receptor
References
- ^ "Structure of the IFNγ Receptor Complex Guides Design of Biased Agonists". doi:10.1038/s41586-019-0988-7. PMC 6561087. PMID 30814731.
- ^ Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC (2003). "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". Biochem. J. 370 (Pt 2): 391–6. doi:10.1042/BJ20021935. PMC 1223207. PMID 12521379.
- ^ Xu W, Presnell SR, Parrish-Novak J, et al. (2001). "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9511–6. doi:10.1073/pnas.171303198. PMC 55483. PMID 11481447.
- ^ Reuter U, Roesler J, Thiede C, Schulz A, Classen CF, Oelschlagel U, Debatin KM, Friedrich W (2002). "Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation". Blood. 100 (12): 4234–5. doi:10.1182/blood-2002-02-0433. PMID 12393576.