DRC may refer to:
- The Democratic Republic of the Congo, a country located in Central Africa
European humanitarianism
- Danish Refugee Council, private Danish humanitarian organisation
- Disability Rights Commission, independent non-departmental public body set up by the British Parliament to end discrimination against disabled people
Places
- The Democratic Republic of the Congo
- Domaine de la Romanée-Conti, a wine estate in Burgundy, France
Technology
- Desktop replacement computer, a personal computer that provides the full capabilities of a desktop computer while remaining mobile
- DRC railcar, a diesel-powered self-propelled railway vehicle in Victoria, Australia
- Design rule checking, area of Electronic Design Automation that determines if a chip design satisfies a series of parameters
- Digital room correction, process in the field of acoustics using digital filters to enhance the input of a sound-reproduction system
- Disaster Recovery Center, a facility for operating with backup equipment and/or data
- Dynamic range compression, process that manipulates the dynamic range of an audio signal
- Dynamic Reaction Cell, room placed before the traditional quadrupole room of an ICP-MS device for eliminating isobaric interferences
- Dynamic recompilation, technique of translating the machine code of one CPU or platform into the native machine code of another for emulation
- DARPA Robotics Challenge
Other
- Dictatorship Resistance Committee
- The Challoner revision of the Douay-Rheims Bible
- Danang Rubber Company, a Vietnam tire company
- Dartford River Crossing, a major road-transport crossing of the River Thames in England
- Detonautas Roque Clube, a Brazilian rock-band
- Democratic Representative Caucus, a group of Canadian Members of Parliament who left the Canadian Alliance in 2001 in protest against the leadership of Stockwell Day
- Democratic Resettlement Community, an informal settlement in Swakopmund, Namibia
- The Disaster Research Center, or DRC, a U.S. organization devoted to the study of disasters
- Domain relational calculus, calculus introduced by Michel Lacroix and Alain Pirotte as a declarative database query language for the relational data model
- Domaine de la Romanée-Conti, wine producer of Burgundy, France
- Dr. Regis Chaperon State Secondary School, a secondary school in Mauritius
- Dynamics Research Corporation, a United States-based publicly held defense contractor
- Dutch Reformed Church, or Nederlandse Hervormde Kerk, a Christian denomination in the Netherlands
- Nederduits Gereformeerde Kerk, (English: "Dutch Reformed Church") in South Africa
- D'ni Restoration Council, fictional organization of the universe of computer game Myst
- Dirico Airport, airport in Angola with IATA code DRC
People
- Dominique Rodgers-Cromartie, an American football player