DFE or DfE may refer to:
Organizations
- Department for the Economy, Northern Ireland
- Department for Education, UK
- DePatie-Freleng Enterprises, a former film animation company
Science
- Dilated fundus examination of the eye
- Distribution of fitness effects
- Dietary folate equivalent, bioavailability of folate
Technology
- Decision-Feedback Equalizer
- Design Focused Evaluation of educational quality
- Design for Environment of a product or service
- DFE Ascender, an ultralight aircraft
Other
- Double Faced Eels, a rock band from Latvia
- Dragon Fli Empire, a Canadian hip hop group
- Dunfermline Town railway station, Scotland, National Rail station code