DSC may refer to:
Academia
- D.Sc., Doctor of Science
- Dalton State College, Georgia
- Daytona State College, Florida
- Deep Springs College, California
- District Selection Committee
- Dixie State University, Utah
- Doctor of Surgical Chiropody, superseded in the 1960s by Doctor of Podiatric Medicine
Science and technology
- .dsc, filename extension for files with description of source package in Debian
- DECT Standard Cipher, an encryption algorithm used by wireless telephone systems
- Differential scanning calorimetry, or the differential scanning calorimeter
- Digital Selective Calling in marine telecommunications
- Digital setting circles on telescopes
- Digital Signal Controller, a hybrid microcontroller and digital signal processor
- Digital Still Camera, used in automatic numbering of files of certain manufacturers within the Design rule for Camera File system (DCF) standard
- Document Structuring Conventions in PostScript programming
- Distributed source coding, a technique regarding the compression of multiple correlated information sources that do not communicate with each other.
- Dye-sensitized solar cell
- Dynamic stability control, computerized technology that improves a vehicle's stability
- Dynamic susceptibility contrast, a type of perfusion MRI
- Desired State Configuration, a feature of Windows PowerShell that enables the deployment and management of configuration data for systems
- Display Stream Compression, a technique part of the VESA standard, used to lower the bandwidth used by a video signal
- Dice similarity coefficient
Government, politics and the military
- Defense Security Command, South Korean military agency
- Distinguished Service Cross (Australia), Australian military award
- Distinguished Service Cross (United Kingdom), British naval award
- Distinguished Service Cross (United States), American military award
- United States District Court for the District of South Carolina
- Directory of Social Change, British charity
Media, sports and entertainment
- Daily Source Code, a podcast by Adam Curry
- Dave, Shelly, and Chainsaw, a long-running morning radio show in the San Diego, California area
- Dresdner SC, a German multisport club playing in Dresden, Saxony
- Dubai Sports City, a multi-venue sports complex in Dubai, United Arab Emirates
- Star Trek: Discovery, an American science fiction television series and part of the Star Trek franchise officially abbreviated to "DSC".
- U.S. Postal Service Pro Cycling Team (UCI code: DSC), a United States-based professional road bicycle racing team
- Dutch Swing College Band
Other
- Down Syndrome Centre, a registered charity in Ireland