DPB may stand for:
Government
- Domestic Purposes Benefit, in the New Zealand social security system
- Defense Policy Board of the U.S. Department of Defense
- Dental Practice Board, a UK government agency now incorporated into the NHS Business Services Authority
Science and technology
- Decoded Picture Buffer, used by video decoders
- USCG deployable pursuit boat, used by the U.S. Coast Guard
- Diffuse panbronchiolitis, a lung disease
- Disinfection by-product, in water treatment
Other uses
- Deer Park Bypass, a freeway in Melbourne, Australia
- Deutscher Pfadfinderbund (1945)
- Discounted Payback, an engineering economics measure
- Dopravný podnik Bratislava, a public transport company in Slovakia