Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
- PI3K-C2α encoded by the PIK3C2A gene
- PI3K-C2β encoded by the PIK3C2B gene
- PI3K-C2γ encoded by the PIK3C2G gene
See also
References
- Stein RC (2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 [1]
- Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.[2]
- Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.[3]