Cartesian anxiety refers to the notion that, since René Descartes posited his influential form of body-mind dualism, Western civilization has suffered from a longing for ontological certainty, or feeling that scientific methods, and especially the study of the world as a thing separate from ourselves, should be able to lead us to a firm and unchanging knowledge of ourselves and the world around us. The term is named after Descartes because of his well-known emphasis on "mind" as different from "body", "self" as different from "other".
Richard J. Bernstein coined the term in his 1983 book Beyond Objectivism and Relativism: Science, Hermeneutics, and Praxis.