CUC may refer to:
In business:
- CUC Broadcasting, a Canadian media company
- CUC International, a Cendant brand
- Caribbean Utilities, a Utilities company based in the Cayman Islands
In education:
- Canadian University College, a private Seventh-day Adventist degree-granting institution and teacher's college in Lacombe, Alberta
- Claremont University Consortium, a group of seven colleges in California
- Columbia Union College, former name for Washington Adventist University, a liberal arts university located in Takoma Park, Maryland, USA
- Combined Universities in Cornwall, a project to provide higher education in Cornwall
- Communication University of China, a university in Beijing, China
- Cuttington University College of Liberia
- Catholic University College, Kensington 19th Century College of Higher Education
- University City of Caracas (Ciudad Universitaria de Caracas), a World Heritage Site and the college campus of Universidad Central de Venezuela
In religion:
- Canadian Unitarian Council, the national body for Unitarian Universalist congregations in Canada
In sports:
- Canadian Ultimate Championships, a national tournament of Ultimate in Canada
In other fields:
- Canadian Unity Council, a non-profit organization whose mission is the promotion of Canadian Unity
- CUC (currency), formerly one of two official currencies in Cuba
- CUC is the IATA airport code for Camilo Daza International Airport, Cúcuta, Colombia
- CUC is the Moldovan version of the famous Russian intellectual game "What? Where? When?" (Chto? Gde? Kogda?)
- CUC is the Committee for Peasant Unity in Guatemala