CME can refer to any of the following:
General
- Chief mechanical engineer, person in charge of building or maintaining locomotives
- Ciudad del Carmen International Airport, Campeche, Mexico
- Computer mediated environment, creation of alternate reality through computer interfaces
- Concurrent Machine Environment, a computing environment supporting ICL Direct Machine Environment
Physiology and medicine
- Chief medical examiner, common official title of a coroner
- Continuing medical education
- Clathrin-mediated endocytosis, another name for receptor-mediated endocytosis (RME)
- Cystoid macular edema, an eye disorder also known as Irvine–Gass syndrome
Science
- Coronal mass ejection, a massive burst of stellar wind and other ejecta from a star
Organizations
- Christian Methodist Episcopal Church, a historically black denomination of Methodism, formerly called "Colored Methodist Episcopal Church"
- Canadian Military Engineers, the military engineer branch of the Canadian Forces
- College of Military Engineering, Pune, a training institution of the Indian Army Corps of Engineers
- World Water Council (Conseil Mondial de l'Eau), an international think-tank focused on water issues
Business
- CME Group, a financial securities exchange services and information firm
- Chicago Mercantile Exchange, a financial and commodity derivative exchange, owned by CME Group
- Central European Media Enterprises
- Central Music Company (CME), Beijing, China
- Columbia Music Entertainment, former name for Nippon Columbia, a record label in Tokyo, Japan
- Creighton Manning Engineering, a civil engineering firm in Albany, New York
- Prince Edward Air, an airline (IATA code CME)