CLR may refer to:
- Calcium Lime Rust, a household cleaning-product
- California Law Review, a publication by the UC Berkeley School of Law
- Centerline Radius, a term in the tubing industry used to describe the radius of a bend
- Central London Railway, an underground railway line in London - now the central part of the London Underground's Central line
- Chief Langalibalele Rifles, an infantry regiment of the South African Army
- Circuit layout record
- Clear instruction in some computer programming assembly languages
- Cliff Hatfield Memorial Airport, an airport in Calipatria, California
- CLR (formerly Computer Language Research), a subsidiary of Thomson Reuters Tax & Accounting
- Coffee leaf rust, a plant disease caused by the fungus Hemileia vastatrix
- Combat Logistics Regiment, a type of United States Marine Corps regiment
- Command, Leadership, Resource management, another acronym for Cockpit Resource Management
- Commando Logistic Regiment, a logistic regiment of the Royal Marines
- Common Language Runtime, the virtual-machine component of Microsoft .NET
- Commonwealth Law Reports, reports of decisions of the High Court of Australia
- Compagnie Luxembourgeoise de Radiodiffusion, a Luxembourg-based radio-broadcaster - part of RTL Group
- Compensation Log Record, a type of database log record
- Council on Library Resources, USA
- Current-Limiting Resistor, an electronic component
- Mercedes-Benz CLR, a racing-car
- The Circle of Liberal Reformers, a political party in Gabon
- A nickname for Introduction to Algorithms by Cormen, Leiserson, and Rivest