CLC may refer to:
Religion
- CLC International, an international Christian literature mission committed to the distribution of the Bible
- Christian Life Community, an international association of lay Christians
- Church of the Lutheran Confession, an American Lutheran denomination
- Concordia Lutheran Conference, a group of Lutheran churches
Schools
- College of Lake County, a community college in Grayslake, Illinois
- Contemporary Learning Center, an alternative school district-operated school in Houston, Texas
- Crystal Lake Central High School, a high school in Crystal Lake, Illinois
Science
- CLC (gene), Charcot-Leyden crystal protein, gene for a human enzyme
- CLC bio, a bioinformatics software company headquartered in Denmark
- Chemical looping combustion
Transportation
- Canadian Locomotive Company
- Columbia and Cowlitz Railway
- Cheshire Lines Committee, a railway in Great Britain
- Clear Lake City STOLport, IATA code for the defunct airport formerly located in southeast Houston
- Mercedes-Benz CLC-Class
Other
- Campaign Legal Center, a U.S. nonprofit working to advance voting rights and transparent democratic processes
- CLC (group), a South Korean girl group
- Cambodian Labour Confederation, a Cambodian national trade union centre
- Canada Lands Company, a Canadian Crown corporation
- Canadian Labour Congress, a Canadian national trade union centre
- Canadian Location Code, for forecast regions
- Chinese Library Classification
- Collegiate Licensing Company
- Combat Logistics Company, units within the United States Marine Corps
- Community legal centres, independent not for profit organisations in Australia
- International Convention on Civil Liability for Oil Pollution Damage, an international maritime treaty
- Crazy Lovely, Cool, Nigerian movie
- Croatian Language Corpus, a text corpus of Croatian compiled at the Institute of Croatian Language and Linguistics