CFR may refer to:
- Caen – Carpiquet Airport in northern France
- Căile Ferate Române, the Romanian state railway
- Canadian Finals Rodeo
- Case fatality rate, term for proportion of people dying of a disease
- Centre for Foreign Relations, Tanzania
- Certified first responder
- CFR Cluj, Romanian football club
- Charter of Fundamental Rights, a charter of political, social and economic rights for European Union (EU) citizens
- Code of Federal Regulations of the United States
- Compact fusion reactor, a proposed nuclear fusion reactor project
- Coronary flow reserve, a diagnostic cardiac measurement
- Cost and Freight, word used in international commerce
- Cross-Functional Requirements, another name for non-functional requirements or the "ilities" in software systems requirements and design
- Council on Foreign Relations, U.S. foreign policy think tank
- 23S rRNA (adenine2503-C2,C8)-dimethyltransferase, an enzyme
- 23S rRNA (adenine2503-C2)-methyltransferase, an enzyme
- Franciscan Friars of the Renewal, a religious institute in the Latin Rite of the Catholic Church commonly abbreviated "C.F.R."