CDF is a three-letter acronym that may refer to:
Mathematics, science, and computers
- .cdf (formerly known as "AIA Format"), the ANDI/netCDF scientific data interchange file format
- Cation diffusion facilitator, transport protein
- Channel Definition Format, an XML standard
- Chip Description File, a genomic analysis file format
- Chlorinated dibenzofuran(s), a.k.a. polychlorinated dibenzofurans
- Cohen–Daubechies–Feauveau wavelet
- Collider Detector at Fermilab
- Comma-delimited format, now referred to as .csv (comma-separated values)
- Common Data Format, NASA software
- Composite Document File, a Microsoft compound document file format
- Compound Document Format, a set of W3C standards on a specific compound document format
- Computable Document Format, a format for interactive data visualizations
- Cumulative distribution function
Organizations
- California Department of Forestry and Fire Protection
- Canal del Fútbol (Chile)
- Ceylon Defence Force
- Chief of the Defence Force (disambiguation), position in multiple countries
- Children's Defense Fund (U.S.)
- Ciskei Defence Force
- Congregation for the Doctrine of the Faith
- Constituency Development Fund (Kenya)
- Cooperative Development Foundation (U.S.)
- Crypto Developers Forum
Other
- Cardiff Central railway station, National Rail station code CDF
- CDF Croisières de France, a cruise ship operator
- Chesapeake Detention Facility
- Clostridium difficile (bacteria)
- ESA's Concurrent Design Facility at ESTEC
- Congolese franc, the ISO 4217 code for the currency of the Democratic Republic of Congo
- Constructive developmental framework for psychological assessment
- Cortina Airport, Italy (IATA code CDF)