The "Big Three" usually describes the three most prominent entities in any given grouping or subject. It may refer to:
Arts and entertainment
- The Big Three television networks in the United States, ABC, CBS, and NBC
- The Big Three (English band)
- The Big 3 (folk group), a folk trio comprising Cass Elliot, Tim Rose, and James Hendricks
- The Big 3 (Milt Jackson album), 1975
Sports
Basketball
- Big3, a professional 3-on-3 basketball league
- Big Three (Boston Celtics, 1980–1992): Larry Bird, Kevin McHale, and Robert Parish
- Big Three (Boston Celtics, 2007–2012): Ray Allen, Kevin Garnett, and Paul Pierce
- Big Three (San Antonio Spurs): Tim Duncan, Manu Ginóbili, and Tony Parker
- Big Three (Miami Heat): LeBron James, Dwyane Wade, and Chris Bosh
Association football
- Big Three (Belgium), the three most successful association football clubs in Belgium
- Big Three (Costa Rica), the three most successful association football clubs in Costa Rica
- Big Three (Greece), the three most successful association football clubs in Greece
- Big Three (Netherlands), the three most successful association football clubs in the Netherlands
- Big Three (Peru), the three most successful association football clubs in Peru
- Big Three (Portugal), the three most successful association football clubs in Portugal
- Big Three (Sweden), the three most successful association football clubs in Sweden
- Big Three (Turkey), the three most successful association football clubs in Turkey
Other sports
- Big Three (tennis): Roger Federer, Rafael Nadal, and Novak Djokovic
- Big Three (hurling), the hurling county teams of Cork, Kilkenny, and Tipperary
Other uses
- Big Three (automobile manufacturers), a country's three largest automobile manufacturers
- Big Three (colleges), Harvard University, Yale University, and Princeton University
- Big Three (credit rating agencies), S&P Global, Moody's Investors Service, and Fitch Ratings
- Big Three (law), three largest law firms in New Zealand (Bell Gully, Chapman Tripp, and Russell McVeagh)
- Big Three (management consultancies), McKinsey & Company, Boston Consulting Group, and Bain & Company
- Big Three television networks, ABC, CBS, and NBC
- Big Three (World War II), the Soviet Union, the United States, and the United Kingdom